Synthesis, characterisation, detection and quantification of a novel hexyl-substituted synthetic cannabinoid receptor agonist: (S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1H-indazole-3-carboxamide (ADB-HINACA)
نویسندگان
چکیده
Synthetic cannabinoid receptor agonists (SCRAs) are a continually evolving family of illicit drugs, with novel analogues frequently being detected. This paper reports the detection new N-hexyl-1H-indazole derivative, ADB-HINACA, within herbal sample seized by law enforcement for first time in United Kingdom. The identity compound was confirmed via synthesis pure ADB-HINACA reference standard and direct spectral comparison 1H NMR GC-EI-MS analysis. A full analytical profiling nuclear magnetic resonance (NMR), attenuated total reflection Fourier-transform infrared (FTIR) spectroscopy gas chromatography-electron ionisation-mass spectrometry (GC-EI-MS) is reported shows good concordance between standard. validated method routine quantification samples (LOD: 1.7 μg/mL, LOQ: 5.8 μg/mL) also developed using this method, determined to contain 4.9% w/w ADB-HINACA.
منابع مشابه
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ژورنال
عنوان ژورنال: Forensic Chemistry
سال: 2021
ISSN: ['2468-1709']
DOI: https://doi.org/10.1016/j.forc.2021.100354